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Why GLP-1 medications cause constipation in the first place Understanding the mechanism matters

After binding to GLP-1 receptors in pancreatic beta cells, GLP-1 RAs exert their glucose-lowering effect by stimulating glucose-dependent insulin release

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Unlike other current weight loss medications on the market, it simultaneously activates three key hormone receptors: GLP-1 receptor GIP receptor Glucagon receptor By targeting all three, Retatrutide delivers a comprehensive approach to weight management by: Suppressing appetite and slowing digestion Enhancing metabolic activity Regulating blood sugar levels Promoting fat breakdown In comparison to other weight loss drugs like Wegovy and Ozempic ( Semaglutide ) that only target GLP-1, while other options like Zepbound and Mounjaro ( Tirzepatide ) activate both GLP-1 and GIP